A carregar...
Publicação
The role of post-translational modifications on STAT3 interactions
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 2 MB | Adobe PDF |
Orientador(es)
Resumo(s)
"The JAK/STAT3 pathway is involved in multiple biological phenomena, mostly related to stress or tissue damage, but also development and cancer. A rate-limiting step of the pathway involves STAT3 dimerization, phosphorylation and translocation to the nucleus. Originally, it was thought that STAT3 dimerized upon phosphorylation by JAKs on Y705. However, current evidence indicates that STAT3 exists as a dimer prior to phosphorylation and activation, and that phosphorylation only induces a change in the conformation of the dimer.(...)"
Descrição
Palavras-chave
JAK/STAT3 pathway STAT3 post-translational modifications BiFC system
Contexto Educativo
Citação
Editora
Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier