Publicação
The role of post-translational modifications on STAT3 interactions
| dc.contributor.author | Ferreira, Joana Grand-Guillaume Perrenoud Silvestre | |
| dc.date.accessioned | 2019-08-26T14:59:19Z | |
| dc.date.available | 2019-09-30T00:30:39Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | "The JAK/STAT3 pathway is involved in multiple biological phenomena, mostly related to stress or tissue damage, but also development and cancer. A rate-limiting step of the pathway involves STAT3 dimerization, phosphorylation and translocation to the nucleus. Originally, it was thought that STAT3 dimerized upon phosphorylation by JAKs on Y705. However, current evidence indicates that STAT3 exists as a dimer prior to phosphorylation and activation, and that phosphorylation only induces a change in the conformation of the dimer.(...)" | pt_PT |
| dc.description.version | N/A | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10362/79296 | |
| dc.language.iso | eng | pt_PT |
| dc.publisher | Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | JAK/STAT3 pathway | pt_PT |
| dc.subject | STAT3 | pt_PT |
| dc.subject | post-translational modifications | pt_PT |
| dc.subject | BiFC system | pt_PT |
| dc.title | The role of post-translational modifications on STAT3 interactions | pt_PT |
| dc.type | master thesis | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Oeiras, Portugal | pt_PT |
| rcaap.embargofct | Artigos por publicar | pt_PT |
| rcaap.rights | embargoedAccess | pt_PT |
| rcaap.type | masterThesis | pt_PT |