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Development of 3D porous structures for buccal drug delivery
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Advances in polymer science and engineering has led to the development of new poly-meric systems for controlled drug delivery in the oral cavity. In this work, pH responsive scaf-folds were prepared by two distinct methods: freeze-drying and gelation process followed by scCO2-assisted drying. The objective was to obtain two distinct porous structures, a gum and a candy to treat oral diseases. The scaffolds of chitosan (CHT), xanthan gum (XG) and polymer m (PM) were prepared with and without crosslinkers (N,N’-methylene-bis-acrylamide (MBA), tet-ramethylenediamine (TEMED) and ammonium persulfate (APS)) in order to find the optimal fea-tures for the purpose of this work. Structures with a wide range of pore sizes and different me-chanical properties, swelling ability and controlled biodegradability were obtained depending on the scaffold composition.
Microarchitectural analysis by scanning electron microscopy demonstrated that it was possible to obtain a wide range of pores, depending on the fabrication process and the poly-mers used. The ability of these structures to release a low molecular weight drug (ibuprofen, Ibu) and a large model protein (BSA) was investigated. Additionally, a mathematical model was adjusted to the experimental release profiles in order to describe the drug release mechanisms.
The tunable morphological and mechanical proprieties together with the ability for the controlled release of bioactive molecules make these structures attractive for pH sensitive sys-tems to treat oral illness.
The preliminary studies indicated that the porous scaffolds showing the best performance as pH sensitive buccal drug delivery systems were: xanthan gum blended with polymer m (XGPM) for the candy scaffold, and xanthan gum blended with chitosan crosslinked with MBA, TEMED and APS (TXGCHT) for the gum scaffold. The quantity of drug release was 60 mg/ g of structure and 75 mg/g of structure, for XGPM and TXGCHT respectively.
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Chitosan Oral illness pH sensitive scaffolds Polymer m Xanthan gum