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From sugar based bio renewable resources to new chemical building blocks and bioactive molecules
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The 4-hydroxycyclopentenones are a family of compounds found in nature, not only with medicinal properties, but can also be used as pesticides. Although with no knowledge of it, traditional medicine used of herbs and plants with healing properties for numerous diseases, which later came to be assign to this family of compounds. Due to its many applications, the synthesis of 4-hydroxycyclopentenones is an area of great interest in chemical research. In this work was applied the method developed by Piancatelli, in furan rings derivatives, with the aim of creating a library of new biologically active 4-hydroxycyclopentenones derivatives. This method has been used for the synthesis of simple cyclopentenones. Excellent yields were obtained by various research groups, having been one of the reasons for the choice of this method. The other was its simplicity, as it’s an acid catalysis reaction with a Lewis acid or even, in a greener version, with microwave catalysis in water.