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Laboratory Evolution of New Bacterial Galactose Oxidases for Green Biotech Applications
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| 3.33 MB | Adobe PDF |
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Resumo(s)
"Galactose oxidases (GalOxs) are copper radical oxidases (CROs) that catalyze the oxidation of primary alcohols to the corresponding aldehydes, reducing molecular oxygen to hydrogen peroxide. These monomeric metalloenzymes have a copper ion as a cofactor and are secreted by filamentous fungi, with FgrGalOx being the best-studied representative. GalOxs holds potential for various biotechnological applications in small molecule synthesis, oxygen removal, and biosensors. Therefore, a better understanding of GalOx from different organisms is crucial, as it may reveal novel or improved properties to be explored in various fields. This work unravels the properties of a new bacterial galactose oxidase, AsGalOx, from Pseudoarthrobacter siccitolerans while simultaneously tailoring its properties through enzyme engineering approaches.(...)"
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Palavras-chave
radical copper oxidases galactose oxidase directed evolution catalytic efficiency