The roles of tubulin post-translational modifications in cancer

Lopes, Danilo

http://hdl.handle.net/10362/150442

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Autores

Lopes, Danilo

Orientador(es)

Maiato, Helder José Martins

Bettencourt-Dias, Mónica

Resumo(s)

"Microtubules are dynamic structures of the cytoskeleton composed by several α/β-tubulin isotypes that may undergo various post-translational modifications (PTMs). This “tubulin code” generates microtubule diversity that modulates key cellular functions. However, whether and how these tubulin PTMs regulate cancer cell properties remains largely unknown. Here, we proposed to understand: (1) the regulation of tubulin PTMs in cancer; (2) the functional implications of the “cancer tubulin code”.