The role of Tubulin Post-Translational Modifications in Human Cancers and During Aging

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The roles of tubulin post-translational modifications in cancer

Publication . Lopes, Danilo; Maiato, Helder José Martins; Bettencourt-Dias, Mónica

"Microtubules are dynamic structures of the cytoskeleton composed by several α/β-tubulin isotypes that may undergo various post-translational modifications (PTMs). This “tubulin code” generates microtubule diversity that modulates key cellular functions. However, whether and how these tubulin PTMs regulate cancer cell properties remains largely unknown. Here, we proposed to understand: (1) the regulation of tubulin PTMs in cancer; (2) the functional implications of the “cancer tubulin code”.

2023-02-22Tese de doutoramento

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Entidade financiadora

Fundação para a Ciência e a Tecnologia

Número da atribuição

SFRH/BD/135077/2017