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Health economic evaluation of Covid-19 vaccines: a systematic literature review
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The outbreak of the COVID-19 pandemic provoked more than six million deaths worldwide between 2019 and 2022 andposed a heavy burden on the healthcare systems. The initial non-pharmaceutical interventions to mitigate the spread of the virus proved to be not sustainable in the long run due to excessive productivity losses. Governments, academic and the private sector invested to produce efficient and safe vaccines. Vaccines are evaluated primarily by their clinical outcomes. However, Health Economic Evaluations of COVID-19 vaccines are also an important tool for policy makers to determine the optimal vaccination strategy in their countries. The existing economic literature about COVID-19 vaccines includes cost-benefit and cost-effectiveness analysis, based on real world evidence (RWE) as well as modelling studies.The objective of this Systematic Literature Review isto report the main evidence from the economic evaluations of the vaccination programsagainst COVID-19that have been made as of summer 2022. Data on key economic outcomes were extracted from 16 scientific papers, selected from an initial list of 1842 studies on the PubMed database. The criteria for inclusion of the studies in this research considered specific restrictions for population, intervention, outcomes, and study design characteristics. The results were then reported following the Cochrane Handbook for Systematic Literature Review. The results indicate that Covid-19 vaccines and vaccination programs are cost-effective and have a positive impact on countries from a social and economic perspective.
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Health economics Vaccines Health economic evaluation & outcome Research Systematic literature review Iqvia