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Publicação
Development of astaxanthin lipid formulations for nutraceutical application: targeting the gastrointestinal epithelium
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Autores
Orientador(es)
Resumo(s)
"Astaxanthin is renowned for its powerful antioxidant activity and remarkable therapeutic effects in the prevention and treatment of several diseases. Moreover, astaxanthin could constitute a potential nutraceutical to be used in the treatment and maintenance of Inflammatory Bowel Diseases. However, its therapeutic use is seriously limited by its instability and low bioavailability. Hence, in this work, astaxanthin and a shrimp shells extract rich in astaxanthin were entrapped into nanostructured lipid carriers (NLCs) and structured lipid carriers (SLCs). Furthermore, their permeability was assessed in a Caco-2 monoculture and in a Caco-2:HT29-MTX:Raji-B triple co-culture. Additionally, their capacity to inhibit reactive species of oxygen (ROS) formation was assessed in Caco-2 monolayers.(...)"
Descrição
Dissertation presented to obtain the Master degree in Biochemistry for Health
Palavras-chave
Astaxanthin Shrimp shell extract Nanostructured lipid carriers Structured lipid carriers
Contexto Educativo
Citação
Editora
Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier