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Publicação
The role of Ubiquitin Specific Protease 7 on Latency Associated Nuclear Antigen DNA binding
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Autores
Orientador(es)
Resumo(s)
The implications of USP7 (Ubiquitin Specific Protease 7, deubiquitinating enzyme involved in several crucial molecular pathways) interactions with LANA (Latency Associated Nuclear Antigen protein, that facilitates the tethering of viral γ-Herpesvirus episomes into the host’s DNA and promotes its replication) has multiple health consequences, since USP7 is a protein that has an essential role it the regulation of many cellular functions, like the p53-mdm2 pathway, that regulates cellular apoptosis and prevents cancer.
Descrição
Dissertation presented to obtain the Master degree in Biochemistry for Health
Palavras-chave
Kaposi’s sarcoma herpesvirus Latency associated nuclear antigen Ubiquitin Specific Protease 7 LANA-USP7 complex Lana Binding Site DNA
Contexto Educativo
Citação
Editora
Universidade Nova de Lisboa. Instituto de Tecnologia Quimica e Biológica António Xavier