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Publicação
The mechanism of the Legionella VipA protein in altering actin dynamics during infection
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Autores
Orientador(es)
Resumo(s)
"Legionella pneumophila is a facultative intracellular bacterium that is commonly found in fresh water and soils, parasitizing a wide range of protozoa hosts. Co-evolution mechanisms allowed this bacterium to parasitize other phagocytic cells and rendered it the ability to become a potential human pathogen. For instance, after inhalation of contaminated aerosols by the host, it can survive and replicate inside human macrophages in the lungs by creating a specialized phagosome that is not degraded, possibly resulting in the severe pneumonia known as Legionnaires’ disease. L. pneumophila relies on a type IV secretion system to inject effector proteins into the host cell to disrupt or take advantage of several cellular processes.(...)"
Descrição
Dissertation presented to obtain the Master Degree in Biochemistry for Health
Palavras-chave
Legionella pneumophila bacterial effector; VipA actin nucleator endocytic pathway
Contexto Educativo
Citação
Editora
Universidade Nova de Lisboa, Instituto de Tecnologiaa Química e Biológica António Xavier