ITQB: SMM- MA Dissertations
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- The mechanism of the Legionella VipA protein in altering actin dynamics during infectionPublication . Carvalho, Ana Teresa Carrilho"Legionella pneumophila is a facultative intracellular bacterium that is commonly found in fresh water and soils, parasitizing a wide range of protozoa hosts. Co-evolution mechanisms allowed this bacterium to parasitize other phagocytic cells and rendered it the ability to become a potential human pathogen. For instance, after inhalation of contaminated aerosols by the host, it can survive and replicate inside human macrophages in the lungs by creating a specialized phagosome that is not degraded, possibly resulting in the severe pneumonia known as Legionnaires’ disease. L. pneumophila relies on a type IV secretion system to inject effector proteins into the host cell to disrupt or take advantage of several cellular processes.(...)"