ITQB: YMB-Master Thesis
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- Exploring the link between iron availability and fluconazole activity against Candida glabrataPublication . Mariano, Carolina"Invasive fungal infections (IFIs) represent a significant health concern worldwide, as recently acknowledged by the World Health Organization with the release of the first priority list of fungal pathogens. Fluconazole remains the most frequently prescribed antifungal for treating IFIs due to its affordability, oral bioavailability, broad spectrum of activity, and safety profile. This triazole drug targets lanosterol 14α-demethylase, Erg11, an enzyme that catalyzes the conversion of lanosterol to ergosterol, whose inhibition arrests cell growth by causing the accumulation of toxic sterols and depletion of ergosterol, which together compromise membrane integrity. Iron overload has been shown to promote fungal growth and is considered a significant risk factor for IFIs. Preliminary results from our laboratory suggest that iron-loading conditions reduce the antifungal activity of fluconazole against Candida glabrata, the second most prevalent cause of these infections.(...)"
- Understanding the effect of iron on the candicidal activity of echinocandinsPublication . Luís, Cláudia"Fungal infections range from superficial skin rashes to health-threatening invasive infections. Invasive candidiasis, caused by the opportunistic yeast Candida spp., is the most common fungal infection among hospitalized patients, being associated with high morbidity and mortality rates. For the treatment of this disease echinocandins are generally the preferred antifungal option because they are fungicidal and potent inhibitors of the fungal enzyme β-1,3-glucan synthetase. Iron overload promotes microbial growth and therefore it is considered a risk factor for many infections. Preliminary results from our laboratory suggest that iron overload may as well affect the efficacy of echinocandins against Candida albicans, putting forward the idea that the availability of iron in the host may interfere with the treatment of serious infections caused by Candida albicans. (...)"