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Emerging roles of the (per)Sulfidome in kidney disease
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Orientador(es)
Resumo(s)
"Hydrogen sulfide (H2S) is a biologically active gasotransmitter with critical
roles in redox regulation, mitochondrial function, and metabolic adaptation to
stress. Endogenous H2S production and degradation are tightly linked to
cysteine availability and are mediated by a network of enzymes that also
influence glutathione metabolism and protein persulfidation. Cysteine thus
serves as a metabolic hub, connecting major redox pathways essential for
maintaining cellular homeostasis. While the roles of H2S and cysteine in
health and disease are increasingly appreciated, how these sulfur metabolic
pathways adapt under sustained oxidative stress, such as chronic hypoxia,
remains poorly understood, particularly in the context of chronic kidney
disease (CKD).(...)"
Descrição
Palavras-chave
chronic kidney disease (CKD) cysteine-centered sulfur metabolism chronic intermittent hypoxia (CIH) sulfur enzymes (per)Sulfidome analysis
Contexto Educativo
Citação
Editora
Instituto de Tecnologia Química e Biológica António Xavier, Universidade NOVA de Lisboa