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Elucidation of Staphylococcus epidermidis response to skin endogenous antimicrobial fatty acids

2026-03-20Tese de doutoramento Acesso embargado
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datacite.subject.fosCiências Naturais::Ciências Biológicas
dc.contributor.authorMorais, Elisabete Cristina Cordeiro
dc.date.accessioned2026-05-06T14:17:33Z
dc.date.available2026-05-06T14:17:33Z
dc.date.issued2026-03-20
dc.description.abstract"Staphylococcus epidermidis is a common human skin coloniser and an opportunistic pathogen related with medical device-associated infections. It presents a dual lifestyle and, according to phylogenetic studies, S. epidermidis strains are grouped into two main lineages: B, composed mainly of isolates colonising skin, and A/C, composed equally of skin-colonising and nosocomial infection isolates. Understanding metabolic and biological features associated with each lineage’s pathogenic and commensal phenotypes is crucial for developing targeted prevention and treatment strategies against S. epidermidis infections. The increased prevalence of S. epidermidis infections, together with the emergence of multidrug-resistant strains, underscores the need for those strategies. This thesis presents comparative studies addressing the metabolic and biological responses of different strains under relevant biological conditions, including pH and the presence of fatty acids. Two phylogenetically distinct strains were selected for comparative analysis: ICE25, belonging to the A/C lineage and representing a strain of higher pathogenic potential, and 19N, from the B lineage and representing a commensal strain.(...)"por
dc.description.sponsorshipDOI 10.54499/UIDB/04612/2020; DOI: 10.54499/UIDP/04612/2020 DOI: 10.54499/LA/P/0087/2020 DOI: 10.54499/UIDB/50011/2020
dc.identifier.urihttp://hdl.handle.net/10362/202884
dc.language.isoeng
dc.publisherInstituto de Tecnologia Química e Biológica António Xavier. Universidade NOVA de Lisboa
dc.relationPD/BD/150980/2021
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectStaphylococcus epidermidis
dc.subjectpathogenicity
dc.subjectcommensalism
dc.subjectenvironmental pH
dc.subjecttime course exometabolomics
dc.subject1H NMR
dc.subjectgenome-scale metabolic models
dc.subjectpan-metabolic network
dc.subjectantimicrobial endogenous fatty acid
dc.titleElucidation of Staphylococcus epidermidis response to skin endogenous antimicrobial fatty acidseng
dc.typedoctoral thesis
oaire.versionhttp://purl.org/coar/version/c_ab4af688f83e57aa

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ITQB: PNMO - PhD Thesis