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Elucidation of Staphylococcus epidermidis response to skin endogenous antimicrobial fatty acids
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Orientador(es)
Resumo(s)
"Staphylococcus epidermidis is a common human skin coloniser and an opportunistic
pathogen related with medical device-associated infections. It presents a dual lifestyle and,
according to phylogenetic studies, S. epidermidis strains are grouped into two main lineages:
B, composed mainly of isolates colonising skin, and A/C, composed equally of skin-colonising
and nosocomial infection isolates. Understanding metabolic and biological features
associated with each lineage’s pathogenic and commensal phenotypes is crucial for
developing targeted prevention and treatment strategies against S. epidermidis infections.
The increased prevalence of S. epidermidis infections, together with the emergence of
multidrug-resistant strains, underscores the need for those strategies. This thesis presents
comparative studies addressing the metabolic and biological responses of different strains
under relevant biological conditions, including pH and the presence of fatty acids. Two
phylogenetically distinct strains were selected for comparative analysis: ICE25, belonging to
the A/C lineage and representing a strain of higher pathogenic potential, and 19N, from the
B lineage and representing a commensal strain.(...)"
Descrição
Palavras-chave
Staphylococcus epidermidis pathogenicity commensalism environmental pH time course exometabolomics 1H NMR genome-scale metabolic models pan-metabolic network antimicrobial endogenous fatty acid
Contexto Educativo
Citação
Editora
Instituto de Tecnologia Química e Biológica António Xavier. Universidade NOVA de Lisboa