Highly water soluble room temperature superionic liquids of APIs

Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/99957

Título:	Highly water soluble room temperature superionic liquids of APIs
Autor:	Carrera, Gonçalo V. S. M. Santos, Miguel M. Costa, Alexandra Rebelo, Luis Paulo N. Marrucho, Isabel M. Nunes da Ponte, M. Branco, Luis C.
Palavras-chave:	PROTIC IONIC LIQUIDS ACTIVE PHARMACEUTICAL INGREDIENTS AMPICILLIN FORMS CIPROFLOXACIN ACID NORFLOXACIN STABILITY LIPOSOMES Catalysis Chemistry(all) Materials Chemistry
Data:	7-Ago-2017
Resumo:	Herein a straightforward approach for the enhancement of the water solubility of common antibiotic and NSAID active pharmaceutical ingredients (APIs) is presented. The APIs are converted into ionic liquids (API-ILs) and molten salts by combination with the organic superbases TMG, DBU and DBN. The prepared superionic liquids were characterized by 1H and 13C NMR as well as FTIR spectroscopy and elemental analysis. Most products are amorphous non-polymorphic room temperature ionic liquids with very high solubility in water, which may enhance the bioavailability of the API-ILs in comparison with the parent drugs.
Descrição:	Fundacao para a Ciencia e a Tecnologia through project (PEst-C/LA0006/2013). The authors also thank Prof. Madalena Dionisio and Dr Natalia Correia for their support with the DSC analyses.
Peer review:	yes
URI:	http://hdl.handle.net/10362/99957
DOI:	https://doi.org/10.1039/c7nj01398a
ISSN:	1144-0546
Aparece nas colecções:	Home collection (FCT)

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Ficheiro	Descrição	Tamanho	Formato
NJChem_MMSantos_2017.pdf		1,24 MB	Adobe PDF	Ver/Abrir