Highly water soluble room temperature superionic liquids of APIs

Carrera, Gonçalo V. S. M.; Santos, Miguel M.; Costa, Alexandra; Rebelo, Luis Paulo N.; Marrucho, Isabel M.; Nunes da Ponte, M.; Branco, Luis C.

http://hdl.handle.net/10362/99957

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Autores

Carrera, Gonçalo V. S. M.

Santos, Miguel M.

Costa, Alexandra

Rebelo, Luis Paulo N.

Marrucho, Isabel M.

Nunes da Ponte, M.

Branco, Luis C.

Resumo(s)

Herein a straightforward approach for the enhancement of the water solubility of common antibiotic and NSAID active pharmaceutical ingredients (APIs) is presented. The APIs are converted into ionic liquids (API-ILs) and molten salts by combination with the organic superbases TMG, DBU and DBN. The prepared superionic liquids were characterized by 1H and 13C NMR as well as FTIR spectroscopy and elemental analysis. Most products are amorphous non-polymorphic room temperature ionic liquids with very high solubility in water, which may enhance the bioavailability of the API-ILs in comparison with the parent drugs.

Descrição

Fundacao para a Ciencia e a Tecnologia through project (PEst-C/LA0006/2013). The authors also thank Prof. Madalena Dionisio and Dr Natalia Correia for their support with the DSC analyses.

Palavras-chave

PROTIC IONIC LIQUIDS ACTIVE PHARMACEUTICAL INGREDIENTS AMPICILLIN FORMS CIPROFLOXACIN ACID NORFLOXACIN STABILITY LIPOSOMES Catalysis General Chemistry Materials Chemistry