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Highly water soluble room temperature superionic liquids of APIs

2017-08-07Artigo científico Acesso aberto
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dc.contributor.authorCarrera, Gonçalo V. S. M.
dc.contributor.authorSantos, Miguel M.
dc.contributor.authorCosta, Alexandra
dc.contributor.authorRebelo, Luis Paulo N.
dc.contributor.authorMarrucho, Isabel M.
dc.contributor.authorNunes da Ponte, M.
dc.contributor.authorBranco, Luis C.
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionInstituto de Tecnologia Química e Biológica António Xavier (ITQB)
dc.contributor.pblRSC - Royal Society of Chemistry
dc.date.accessioned2020-06-25T22:52:42Z
dc.date.available2020-06-25T22:52:42Z
dc.date.issued2017-08-07
dc.descriptionFundacao para a Ciencia e a Tecnologia through project (PEst-C/LA0006/2013). The authors also thank Prof. Madalena Dionisio and Dr Natalia Correia for their support with the DSC analyses.
dc.description.abstractHerein a straightforward approach for the enhancement of the water solubility of common antibiotic and NSAID active pharmaceutical ingredients (APIs) is presented. The APIs are converted into ionic liquids (API-ILs) and molten salts by combination with the organic superbases TMG, DBU and DBN. The prepared superionic liquids were characterized by 1H and 13C NMR as well as FTIR spectroscopy and elemental analysis. Most products are amorphous non-polymorphic room temperature ionic liquids with very high solubility in water, which may enhance the bioavailability of the API-ILs in comparison with the parent drugs.en
dc.description.versionauthorsversion
dc.description.versionpublished
dc.format.extent5
dc.format.extent1265477
dc.identifier.doi10.1039/c7nj01398a
dc.identifier.issn1144-0546
dc.identifier.otherPURE: 3838175
dc.identifier.otherPURE UUID: 741bcee3-7469-4c00-8a79-a60405fc6c01
dc.identifier.otherScopus: 85026320974
dc.identifier.otherWOS: 000406192800007
dc.identifier.otherORCID: /0000-0003-4499-4521/work/51947945
dc.identifier.otherORCID: /0000-0001-8973-1595/work/75127764
dc.identifier.otherORCID: /0000-0002-5247-2443/work/105033663
dc.identifier.urihttp://hdl.handle.net/10362/99957
dc.identifier.urlhttps://www.scopus.com/pages/publications/85026320974
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/103664/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F72095%2F2010/PT
dc.subjectPROTIC IONIC LIQUIDS
dc.subjectACTIVE PHARMACEUTICAL INGREDIENTS
dc.subjectAMPICILLIN
dc.subjectFORMS
dc.subjectCIPROFLOXACIN
dc.subjectACID
dc.subjectNORFLOXACIN
dc.subjectSTABILITY
dc.subjectLIPOSOMES
dc.subjectCatalysis
dc.subjectGeneral Chemistry
dc.subjectMaterials Chemistry
dc.titleHighly water soluble room temperature superionic liquids of APIsen
dc.typejournal article
degois.publication.firstPage6986
degois.publication.issue15
degois.publication.lastPage6990
degois.publication.titleNew Journal of Chemistry
degois.publication.volume41
dspace.entity.typePublication
oaire.awardNumberPTDC/CTM/103664/2008
oaire.awardNumberSFRH/BPD/72095/2010
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM%2F103664%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F72095%2F2010/PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublicationb6f2e64c-d04e-4f6c-a7ac-75aa1609e46d
relation.isProjectOfPublication1a5e509a-90b1-41f4-8144-7e07e0eb8269
relation.isProjectOfPublication.latestForDiscovery1a5e509a-90b1-41f4-8144-7e07e0eb8269

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