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Towards novel stem cell and protein based therapies for myocardium regeneration
| Nome: | Descrição: | Tamanho: | Formato: | |
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| 7.28 MB | Adobe PDF |
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Orientador(es)
Resumo(s)
"Acute Myocardial Infarction (AMI) remains a leading cause of death
worldwide. After AMI, clinical restauration of blood flow aggravates tissue
damage (Ischemia/Reperfusion, I/R injury), critically decreasing the
number of viable cardiomyocytes (CMs). Besides CMs, other myocardial
cell populations such as cardiac stem/progenitor cells (CSCs) and
cardiac fibroblasts (CFs) play key roles in tissue pathology and
regeneration upon AMI. Several studies have demonstrated the relevant
role of endogenous CSCs in myocardial repair after I/R injury, supported
by the establishment of a paracrine cross talk between CSCs and the
injured tissue(...)".
Descrição
Palavras-chave
myocardial human cardiac cell