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Projeto de investigação

CARDIOSTEM- Engineered cardiac tissues and stem cell-based therapies for cardiovascular applications

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Unveiling human Cardiac Stem Cells role in myocardial ischemia-reperfusion injury
Publication . Reis, Ivo Miguel Ferreira da Paixão; Alves, Patrícia
2018-11-05Dissertação de mestrado Acesso aberto Ver mais
Towards novel stem cell and protein based therapies for myocardium regeneration
Publication . Sebastião, Maria; Alves, Paula Marques; Serra, Maria Margarida; Alves, Patrícia Gomes
"Acute Myocardial Infarction (AMI) remains a leading cause of death worldwide. After AMI, clinical restauration of blood flow aggravates tissue damage (Ischemia/Reperfusion, I/R injury), critically decreasing the number of viable cardiomyocytes (CMs). Besides CMs, other myocardial cell populations such as cardiac stem/progenitor cells (CSCs) and cardiac fibroblasts (CFs) play key roles in tissue pathology and regeneration upon AMI. Several studies have demonstrated the relevant role of endogenous CSCs in myocardial repair after I/R injury, supported by the establishment of a paracrine cross talk between CSCs and the injured tissue(...)".
2018-09-19Tese de doutoramento Acesso aberto Ver mais
Towards a bioinspired 3D triculture hiPSC-derived cardiac tissue model for human heart microenvironment recapitulation and drug testing
Publication . Costa, Pedro Gustavo Marchã Canhão; Alves, Paula; Serra, Maria Margarida
2018-11-05Dissertação de mestrado Acesso aberto Ver mais

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Entidade financiadora

Fundação para a Ciência e a Tecnologia

Programa de financiamento

5665-PICT

Número da atribuição

MITP-TB/ECE/0013/2013

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