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Dissecting the rules underlying de novo centrosome biogenesis
| Nome: | Descrição: | Tamanho: | Formato: | |
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| 92.55 MB | Adobe PDF |
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Resumo(s)
"The centrosome is the main microtubule organising centre
(MTOC) in animal cells, regulating cell motility and polarity during
interphase and organising the mitotic spindle in mitosis. Each
centrosome has two centrioles, a mother and a daughter, which are
surrounded by a multi-layered protein network called pericentriolar
material (PCM) (Loncarek and Bettencourt-Dias, 2018; Nigg and
Holland, 2018). The PCM contains critical components that anchor
and nucleate microtubules (MTs). Centriole biogenesis is a highly
regulated process that occurs only once per cell-cycle in proliferating
cells (Breslow and Holland, 2019).(...)"
Descrição
Palavras-chave
centrosome cell-cycle