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Polypyrrole functionalized electrospun fibers for electrically stimulated drug release
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Orientador(es)
Resumo(s)
Current infection therapies often require oral and topical drug administration. Over
the years, several studies have proven the lack of efficiency that characterizes these treatments.
This work is focused on the development of an innovative biocompatible drug support,
obtained by electrospinning using a polymer (Cellulose Acetate) with a drug model
(Rhodamine B), resulting on a nanofiber mat with the drug encapsulated. The encapsulation
was tested in both conventional and coaxial setups. The optimized membranes
were also functionalized with a conductive polymer (polypyrrole) to test electrical drug
delivery activation. Drug release profiles performed with passive (diffusion) and active
stimulation (electrical stimulus) were analyzed and compared.
The results obtained allowed to conclude that both types of membranes (conventionally
or coaxially produced) were uniformly polymerized 45 minutes after the beginning
of the polymerization process. Moreover, positive stimulus polarity proved to induce a
higher response in terms of drug release. Additionally, different studies were also performed
with the aim of obtaining a better control over the released amount and release
instants, being therefore studied the sensibility of the membranes to a switchable-like
profile. As a result, it could be concluded that the higher the applied voltage, the closer
the obtained release profile was from an “on-off” pattern.
Descrição
Palavras-chave
electrospinning coaxial electrospinning drug delivery system cellulose acetate rhodamine b polypyrrole