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Production and study of nano-Hydroxyapatite cement for bone tissue substitution and regeneration
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Resumo(s)
Hydroxyapatite (HAp) is a bioceramic particularly suitable for biomedical applications in fields of dentistry and orthopaedics due to its osteoconductivity and biocompatibility, associated with the resemblance of its chemical composition to that of the mineral phase of the human bone. A mesoporous structure increases the bioactivity of hydroxyapatite nanopowders and facilitates the adsorption of drugs. Since the late 80’s, bone cements and pastes have been developed to fill bone defects helping in the regeneration of bone tissue and aiming towards minimally-invasive techniques in the treatment of bone defects.
This study aims to produce and study a mesoporous hydroxyapatite (MHAp) cement by mixing MHAp powder, synthesized via sol-gel method, with a liquid solution of hydroxypropylmethylcellulose (HPMC) as a gelling agent. Different concentrations of HPMC and the liquid/solid (L/S) ratio were tested.
The MHAp powders produced were analysed using FTIR and XRD to assess their chemical composition and crystalline structure, TEM analysis was made to determine the particle and porous size, and finally, cytotoxicity tests were made to test the powders viability. The MHAp cements were submitted to injectability assays, setting time tests and cytotoxicity tests.
All MHAp cements produced are injectable, bioactive and biocompatible. Furthermore, they present setting times which are adequate for the powder and liquid to be mixed and placed into a syringe. Possibility of changing the setting time by changing the liquid solution or the L/S ratio deserves further studies.
Descrição
Palavras-chave
Mesoporous hydroxyapatite minimally-invasive techniques MHAp cement hydroxypropylmethylcellulose injectable