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http://hdl.handle.net/10362/85353
Título: | Multilevel impacts of iron in the brain |
Autor: | Ferreira, Ana Neves, Pedro Gozzelino, Raffaella |
Palavras-chave: | Brain Cognition Iron Neurophysiology Social behavior Molecular Medicine Pharmaceutical Science |
Data: | 1-Set-2019 |
Resumo: | Iron is a critical element for most organisms, which plays a fundamental role in the great majority of physiological processes. So much so, that disruption of iron homeostasis has severe multi-organ impacts with the brain being particularly sensitive to such modifications. More specifically, disruption of iron homeostasis in the brain can affect neurophysiological mechanisms, cognition, and social behavior, which eventually contributes to the development of a diverse set of neuro-pathologies. This article starts by exploring the mechanisms of iron action in the brain and follows with a discussion on cognitive and behavioral implications of iron deficiency and overload and how these are framed by the social context. Subsequently, we scrutinize the implications of the disruption of iron homeostasis for the onset and progression of psychosocial disorders. Lastly, we discuss the links between biological, psychological, and social dimensions and outline potential avenues of research. The study of these interactions could ultimately contribute to a broader understanding of how individuals think and act under physiological and pathophysiological conditions. |
Descrição: | Funding agencies: A.F. is funded by national funds through the FCT – Fundação para a Ciência e a Tecnologia, I.P., under the Norma Transitória – DL57/2016/CP1453/CT0077, and receives research funding from FCT/MCTES grant PTDC/IVC-ESCT/0073/2014. PN is funded through FCT – Fundação para a Ciência e a Tecnologia (UID/ECO/00124/2013, UID/ECO/00124/2019 and Social Sciences DataLab, LISBOA-01-0145-FEDER-022209), POR Lisboa (LISBOA-01-0145-FEDER-007722, LISBOA-01-0145-FEDER-022209), and POR Norte (LISBOA-01-0145-FEDER-022209). RG is funded by FCT – Fundação para a Ciência e a Tecnologia (IF/01495/2015) and receives research funding from FCT-PAC (03/SAICT/2015) and EOS MODEL-IDI 30826052. A.F., P.N., and R.G. also received research funding from Santander Totta/NOVA University of Lisbon (Collaborative Investigation Price 2017). UID/SOC/04647/2019 DL 57/2016/CP1453/CT0077 |
Peer review: | yes |
URI: | http://www.scopus.com/inward/record.url?scp=85073368056&partnerID=8YFLogxK |
DOI: | https://doi.org/10.3390/ph12030126 |
ISSN: | 1424-8247 |
Aparece nas colecções: | Social Sciences DataLab Home collection (NSBE) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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pharmaceuticals_12_00126.pdf | 740,04 kB | Adobe PDF | Ver/Abrir |
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