ITQB: NBPT- MA Dissertation
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- Development of astaxanthin lipid formulations for nutraceutical application: targeting the gastrointestinal epitheliumPublication . Prazeres, Inês"Astaxanthin is renowned for its powerful antioxidant activity and remarkable therapeutic effects in the prevention and treatment of several diseases. Moreover, astaxanthin could constitute a potential nutraceutical to be used in the treatment and maintenance of Inflammatory Bowel Diseases. However, its therapeutic use is seriously limited by its instability and low bioavailability. Hence, in this work, astaxanthin and a shrimp shells extract rich in astaxanthin were entrapped into nanostructured lipid carriers (NLCs) and structured lipid carriers (SLCs). Furthermore, their permeability was assessed in a Caco-2 monoculture and in a Caco-2:HT29-MTX:Raji-B triple co-culture. Additionally, their capacity to inhibit reactive species of oxygen (ROS) formation was assessed in Caco-2 monolayers.(...)"
- Establishment of bioengineered glucose-responsive nanoparticles for type 2 diabetes mellitus therapyPublication . Fonseca, Filipa Ribeiro da"Type 2 diabetes mellitus (T2DM) is one of the biggest health problems in the world. Glucagon like peptide-1, an endogenous gastrointestinal incretin hormone that stimulates insulin secretion, is considered an attractive therapeutic agent for T2DM treatment. Nevertheless, its short half-life has led to the development of longer half-life GLP-1 analogues, as exenatide. Still, current dosage forms for exenatide delivery are not exempt of shortcomings. Nanotechnology-based systems may offer several advantages over conventional dosage forms for drug delivery.(...)"
- Exploring the potential of natural extracts obtained from winemaking waste streams for cosmetic applicationsPublication . Matos, Melanie S."Phenolic compounds present in grapes have been widely explored as cosmetic principles, because of their renowned antioxidant activity and proven ability to directly inhibit certain enzymes relevant for skin ageing. The winemaking process generates large amounts of waste streams, thus recovery of phenolic bioactive compounds from residues and further incorporation in cosmetic products represents a promising market opportunity for wine producers, and may contribute to a sustainable development of the sector.(...)"