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Publicação
Production, Biochemical Characterisation and Stability Assessment of Human IgG4 Therapeutic Antibodies in Comparison to Other Isotypes
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Autores
Orientador(es)
Resumo(s)
"Therapeutic antibodies and antibody derivatives comprise the majority of today’s biotherapeutics. Their stability, resistance to stress conditions and high solubility have allowed the successful development and commercialization of over 40 antibody-based drugs. These antibodies are, in their majority, based on the IgG1 isotype, and are capable of evoking effector functions as ADCC and CDC. However there has been an increased interest in producing other antibody formats like IgG2, IgG4S228P or aglycosylated IgG1s when effector functions are unnecessary or unwanted.(...)"
Descrição
Palavras-chave
Anticorpo monoclonal Isótipo de IgG Caracterização comparativa Estabilidade de anticorpo Agregação proteica Fragmentação
Contexto Educativo
Citação
Editora
Instituto de Tecnologia Química e Biológica António Xavier. Universidade Nova de Lisboa