ITQB: BC - MA Dissertations
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- Design, synthesis and biological evaluation of new derivatives of phenolic metabolitesPublication . Carregosa, Diogo; Ventura, Rita; Santos, Cláudia"Multiple (poly)phenolic compounds, related with the consumption of dietary products have been described to modulate microglial cells, influencing the inflammatory response in the brain and microgliamediated neuronal apoptosis. However, low amounts of information is available about small compounds, present in human blood circulation after the metabolization of (poly)phenols. Previously we have shown some of these small metabolites, capable of crossing the blood brain barrier at physiological concentrations, and be neuroprotective.(...)"
- Chemical synthesis of new histone deacetylase inhibitors and their evaluation as inducers of recombinant protein production in plantsPublication . Rebelo, Bárbara Almeida; Ventura, Rita; Abranches, Rita"Transgenic plants offer several advantages for the production of recombinant proteins with pharmaceutical value. Moreover, plant suspension cell cultures combine the benefits of plants with the advantages of recombinant protein production by microbial cell cultures. Histones are proteins that are essential in gene expression control through several modifications like acetylation, phosphorylation and methylation. Histone acetyltransferases and histone deacetylases regulate the expression levels via acetylation and deacetylation of lysine residues in histones. Therefore, histone acetylation is associated with an increase in transcription levels, resulting in higher protein production levels. Inhibitors of these HDACs have been associated with the treatment of prostate and lymphoma cancer, reactivation of latent HIV cells and they also behave as small molecular enhancers for recombinant protein production.(...)"
- Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agentsPublication . Diana O. Silva; Ventura, Rita"Epigenetics and its key role in gene expression have become increasingly important in cancer research. Histone proteins play an important role in gene expression control through modifications like acetylation, phosphorylation and methylation. Histone deacetylases (HDAC) can regulate expression levels via acetylation of lysine residues of histone proteins.(...)"