The Role of PKCs In Morphogenesis

Abstract

For cells to form tissues and organs, they have to coordinate individual cell shape with tissue morphogenesis. To achieve that, cellular adhesion and actin-myosin cytoskeleton contractility need to be coordinated from the cell to the tissue level. In my thesis I focused on the hypothesis that Protein Kinase Cs (PKCs), has central RhoGTPase signaling effectors, are important regulators of cell shape and tissue integrity during morphogenesis.