DEFINING NOVEL MECHANISMS REQUIRED FOR THE FORMATION AND MORPHOGENESIS OF A POLARIZED EPITHELIUM

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Publication . Ferreira, Tânia Catarina; Martinho, Rui; Jacinto, António

For cells to form tissues and organs, they have to coordinate individual cell shape with tissue morphogenesis. To achieve that, cellular adhesion and actin-myosin cytoskeleton contractility need to be coordinated from the cell to the tissue level. In my thesis I focused on the hypothesis that Protein Kinase Cs (PKCs), has central RhoGTPase signaling effectors, are important regulators of cell shape and tissue integrity during morphogenesis.

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Fundação para a Ciência e a Tecnologia

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SFRH/BD/37587/2007