ITQB: MNH- MA Dissertation
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- Modulation of neuroinflammation by phenolic sulfates metabolitesPublication . Bastos, Ana Catarina Alves"Within the central nervous system, microglial cells are key regulators of a set of inflammatory processes. The microglial inflammatory response is the main contributor to the process of neuroinflammation. Inside the brain, under certain abnormal conditions, a sustained microglial activation may lead to an exacerbation of the inflammatory state, causing chronic pathological conditions such as neurodegeneration. (...)"
- Design de plataformas enzimáticas e magnéticas para produção de compostos bioativos em microreatorPublication . Lage, Patrícia Vanessa da Cunha"Rhamnopyranosidase (Rhmnase) is an enzymatic complex that expresses a-L-ramnosidase (EC 3.2.1.40) and b-D-glucosidase (EC 3.2.1.21), and responsible for natural flavonoids hydrolysis. These flavonoid aglycones represent potential drugs, essentially due to their antioxidant and antiinflammatory properties and their increased bioavailability in the human body ."
- Unraveling phytochemicals with potential therapeutic application for neurodegenerationPublication . Vaz, Marcela Tatiana Barros"Epidemiological data suggest that phytochemicals may prevent and even reverse specific pathological processes underlying neurodegenerative diseases. A (poly)phenol-enriched fraction from leaves of Corema album was previously reported to modulate central events related to α-Synuclein expression and aggregation as well as oxidative stress in eukaryotic models of Parkinson’s disease. In order to identify the potentially bioactive compound, this extract was subjected to a bioguided fractionation, leading to the identification of CAL_X.(...)"
- Protective activity of phytochemicals from natural extractsPublication . Girlus, Elena ValeriaThe rise in the incidence of neurodegenerative diseases leads to an increased demand for the development of alternative therapeutic strategies. Phytochemicals have proved beneficial effects for human health, exerting protective roles towards several diseases including neurodegenerative disorders. Thus, the search for new bioactivities is a field in constant growth. The beet and fruits belonging to Opuntia spp. are rich in betalains and phenolic compounds, which confer several benefits to human health such as regulators of antioxidant and anti-inflammatory responses as well as potential protective effect for chronic diseases.