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Structural and functional investigation of type II NADH:quinone oxidoreductase from the pathogenic bacteria Vibrio cholerae and Staphylococcus aureus
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Resumo(s)
Staphylococcus aureus and Vibrio cholerae are two pathogenic bacteria that, on their own, are responsible for more than 150,000 human deaths per year (affecting almost 5,000,000 people worldwide). Antibiotics and vaccines have been proved to work as a viable strategy to treat bacterial related epidemics such as cholera and MRSA associated infections. Nevertheless, new drugs are increasingly necessary due to the appearance of resistant strains.