ITQB: CGE - MA Dissertations
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- Biochemical and Biophysical Characterization of Exoribonucleases from the Human Pathogen Mycobacterium TuberculosisPublication . Costa, Vanessa G; Matos, Rute; Brito, José"Mycobacterium tuberculosis, the causative agent of tuberculosis, remains the leading cause of mortality from a single infectious organism, infecting nearly one-third of the global population. Emergence of multidrug and extremely drug resistant strains of M. tuberculosis represents a serious health problem and emphasizes the need to improve prevention and control of the disease. Regulation of gene expression through RNA metabolism is a key mechanism for bacterial growth, division and rapid accommodation to environmental conditions. Ribonucleases ensure maturation, degradation and quality control of RNA in all domains of life. (...)"
- DISCOVERING NOVEL PSEUDOMONAS AERUGINOSA SMALL NON-CODING RNAs INVOLVED IN BIOFILM AND ANTIBIOTIC RESISTANCE MECHANISMSPublication . Remendinho da Silva, Joana; Pobre, Vânia; Arraiano, Cecília"Pseudomonas aeruginosa is an opportunistic pathogen capable of infecting immunocompromised patients, especially patients with cystic fibrosis. When left untreated, infections result in lung failure and the death of patients. P. aeruginosa is very difficult to treat due to its strong resistance to several classes of antibiotics, as well as its ability to develop into multidrug-resistant (MDR) bacteria and form biofilms. Consequently, it is essential to develop alternative strategies to combat antibiotic resistance, such as therapies based on small RNAs (sRNAs). These molecules play an important role in gene expression and have been shown to affect antibiotic resistance and sensitivity in P. aeruginosa. However, knowledge about sRNAs in this Gram-negative bacterium is still very limited.(...)"
- Molecular killers in Streptococcus pneumoniae: RNase R and the control of other ribonucleasesPublication . José Caetano dos Santos, Fábio"Streptococcus pneumoniae causes several diseases, namely bacterial pneumonia. Current prevention and therapies are insufficient, and it is a priority to find new solutions. The successful colonization and invasion, by pneumococcus are the result of a number of pathogenic mechanisms tightly coordinated through ribonucleases (RNases). RNase R, RNase III and YbeY are known to have roles in the regulation of virulence genes, in response to stress conditions, and in the maturation of ribosomal RNA (rRNA), affecting protein synthesis.(...)"