ITQB: G - MA Dissertations
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- Investigating chitotriosidase and glycosyltransferase GLT8D1 in Amyotrophic Lateral SclerosisPublication . Felgueiras, Beatriz; Costa, Júlia"Amyotrophic lateral sclerosis (ALS) is a neurodegenerative neuromuscular disease causing motor neuron dysfunction. The identification of ALS biomarkers is of great importance in diagnosis, monitoring of disease progression and understanding of disease etiology. The aim of this thesis was to investigate two proteins related with ALS pathology. First, the potential of plasma chitotriosidase (CHIT1) as ALS biomarker has been investigated. Second, the enzyme glycosyltransferase 8 domain-containing protein 1 (GLT8D1), recently found mutated in familial cases of ALS, has been characterized.(...)"
- Protein glycosylation of extracellular vesicles from ovarian carcinoma cellsPublication . Gomes, Joana Raquel Afonso; Costa, JúliaExtracellular vesicles (EVs) are released by almost all types of cells, including tumor, immune and stem cells, and are also present in body fluids like saliva, urine, breast milk and malignant ascites. EVs have a unique cargo of proteins, lipids and nucleic acids, and conserve characteristics from donor cells.