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Electronic detection of neurological signalling agents
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This project will advance knowledge within the realm of neurological signalling agents/neu-rotransmitters and other biomarkers of disease. Electrochemistry is a valuable interrogation tool for quantitative analysis of such redox species.
One main goal is to overcome problems inherent to the simultaneous detection of neuro-transmitters, such as overlapping redox potentials and electrode fouling due to build-up of surface oxidation products. The use of electrodeposited catalysts enables selective detection in multicom-ponent systems at the required physiological levels. The carbon-based nanoparticles used in this work showed good potential when it comes to solve these problems.
Another goal is to explore the viability of a smartphone-operated potentiostat system in the electrochemical detection of neurotransmitters. Phone systems have been used in electrochemical formats for electroactive substances detection, but, to our knowledge, have not been employed as AC signal generators for amperometric sensor signal acquisition. The system appeared to work correctly. However, it needs additional tests and hardware and software development. It seems to be a good option to facilitate the electrochemical detection process, being low-cost, fast and port-able.
Finally, another goal is to explore the electrochemical properties of galectin-3, protein that has been considered regarding investigations of concussion and cancer biomarkers. Some en-zyme-linked immunosorbent assays for its optical detection already exist. As far as we know, electrochemistry is a novel approach for the detection of galectin-3 in biological fluids. The re-sults showed correlation between the optical and electrochemical data, which is a good indicator of the success of the electrochemical approach. The positive results obtained with each approach validate the work, which is a good summary of areas that can be improved when it comes to the usage of electrochemistry in diagnostic.
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electrochemistry neurotransmitters electrode modification galectin-3