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Improved Particle Engineering and DPI Formulation for Optimal Pulmonary Delivery
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| 10.59 MB | Adobe PDF |
Orientador(es)
Resumo(s)
The pharmaceutical interest to deliver drugs to the lungs has been increasing to
treat local diseases like asthma or for systemic treatment, as insulin for diabetics.
Pulmonary drug delivery enables a rapid drug action and bioavailability while avoiding
the first pass metabolism and reducing the drug load required, minimizing adverse side
effects and creating a more efficient therapy.
The main goal of this work was to investigate, benchmark and optimize the
different formulations and process parameters of the particle engineering technologies
in order to optimize pulmonary drug delivery in dry powder inhalers.(...)
Descrição
Palavras-chave
Dry powder inhalers Carrier-based formulation Carrier-free formulation Multicomponent particles Particle engineering Jet-milling