Publicação
Improved Particle Engineering and DPI Formulation for Optimal Pulmonary Delivery
| datacite.subject.fos | Engenharia e Tecnologia::Engenharia Química | pt_PT |
| dc.contributor.advisor | Ricardo, Ana | |
| dc.contributor.advisor | Costa, Eunice | |
| dc.contributor.author | Moura, Cláudia Consuelo Vieira Reis Leite | |
| dc.date.accessioned | 2017-05-25T21:10:56Z | |
| dc.date.embargo | 2027 | |
| dc.date.issued | 2016-09 | |
| dc.date.submitted | 2017-05 | |
| dc.description.abstract | The pharmaceutical interest to deliver drugs to the lungs has been increasing to treat local diseases like asthma or for systemic treatment, as insulin for diabetics. Pulmonary drug delivery enables a rapid drug action and bioavailability while avoiding the first pass metabolism and reducing the drug load required, minimizing adverse side effects and creating a more efficient therapy. The main goal of this work was to investigate, benchmark and optimize the different formulations and process parameters of the particle engineering technologies in order to optimize pulmonary drug delivery in dry powder inhalers.(...) | pt_PT |
| dc.identifier.tid | 101548362 | |
| dc.identifier.uri | http://hdl.handle.net/10362/20779 | |
| dc.language.iso | eng | pt_PT |
| dc.relation | PT2020 (POCI-01-0145-FEDER - 007265) | pt_PT |
| dc.relation | Associated Laboratory for Green Chemistry - Clean Technologies and Processes | |
| dc.subject | Dry powder inhalers | pt_PT |
| dc.subject | Carrier-based formulation | pt_PT |
| dc.subject | Carrier-free formulation | pt_PT |
| dc.subject | Multicomponent particles | pt_PT |
| dc.subject | Particle engineering | pt_PT |
| dc.subject | Jet-milling | pt_PT |
| dc.title | Improved Particle Engineering and DPI Formulation for Optimal Pulmonary Delivery | pt_PT |
| dc.type | doctoral thesis | |
| dspace.entity.type | Publication | |
| oaire.awardNumber | UID/QUI/50006/2013 | |
| oaire.awardTitle | Associated Laboratory for Green Chemistry - Clean Technologies and Processes | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F50006%2F2013/PT | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | embargoedAccess | pt_PT |
| rcaap.type | doctoralThesis | pt_PT |
| relation.isProjectOfPublication | 775f329d-0338-4890-916f-14d92a2c2b21 | |
| relation.isProjectOfPublication.latestForDiscovery | 775f329d-0338-4890-916f-14d92a2c2b21 | |
| thesis.degree.name | Doutoramento em Química Sustentável | pt_PT |