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Functional and genetic analysis of alpha-synuclein and huntingtin in Drosophila melanogaster
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In this work we established new transgenic Drosophila models for
Parkinson’s (PD) and Huntington’s disease (HD), two incurable devastating
human neurodegenerative diseases, which strongly compromise the patients’
motor abilities. Our Drosophila models are based on the transgenic
overexpression of fluorescent-tagged versions of two human neuronal proteins
extensively associated with these neuropathologies, but whose exact
biological function is still unknown: alpha-synuclein (α-syn) for PD and
huntingtin (Htt) for HD.(...)
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Neuroscience