NEURODEGENERATION AND ER STRESS IN DROSOPHILA

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Functional and genetic analysis of alpha-synuclein and huntingtin in Drosophila melanogaster

Publication . Poças, Gonçalo; Domingos, Pedro

In this work we established new transgenic Drosophila models for Parkinson’s (PD) and Huntington’s disease (HD), two incurable devastating human neurodegenerative diseases, which strongly compromise the patients’ motor abilities. Our Drosophila models are based on the transgenic overexpression of fluorescent-tagged versions of two human neuronal proteins extensively associated with these neuropathologies, but whose exact biological function is still unknown: alpha-synuclein (α-syn) for PD and huntingtin (Htt) for HD.(...)

2015-12-16Tese de doutoramento

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Entidade financiadora

Fundação para a Ciência e a Tecnologia

Número da atribuição

SFRH/BD/61477/2009