ITQB: MNH - PhD Theses
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- Disclosing the mechanisms underlying the beneficial effects of berries-driven polyphenols: In in vitro, as well as in vivo cardiovascular modelsPublication . Gomes, Andreia; Nunes dos Santos, Cláudia; Brenner, Catherine"Nowadays, cardiovascular diseases (CVD) constitute a major health problem accounting for about 30% of deaths worldwide. Diet, one of the most important lifestyle risk factors, can strongly influence CVD progression and might afford a promising prophylaxis. Epidemiological studies have shown a consistent beneficial relationship between the consumption of fruits and vegetables, rich sources of (poly)phenols, and a reduced risk of CVD susceptibility. Abundant dietary (poly)phenols in our diet are not necessarily able to result in the highest tissue concentrations, owing to considerable differences in bioavailability. Thus, a detailed and profound knowledge on the (poly)phenols metabolic fate and the specific bioactive (poly)phenol metabolites and their molecular targets is a key point to ensure the safe use of these active phytochemicals as a nutraceutical and or therapeutic agent in a nearest future.(...)"
- Deciphering the potential of berries polyphenol metabolites for Parkinson’s DiseasePublication . Figueira, Inês Margarida Lourenço"This thesis is organized in five parts: introduction, three chapters of experimental work and a general discussion. In the introduction section, major topics necessary for a broad comprehension of this thesis is described. Major aspects about neurodegenerative diseases and (poly)phenols importance in the disease prevention are present. State of art of major cellular models used for studying (poly)phenols role in Parkinson’s disease (PD) is also described. Emphasis to the knowledge gaps of (poly)phenols potential to act inside the brain was considered such as their ability to cross and/or interact with the blood-brain barrier (BBB). Finally, a thesis rational and major work objectives are concluding the introductory section. Part of this section was included in a review published in Current Neuropharmacology.(...)"
- Investigating the neuroprotective effect of plant (poly)phenols in models of Parkinson´s diseasePublication . Macedo, DianaParkinson’s disease (PD) is the second most common neurodegenerative disease, and affects 1-2% of the population worldwide after the age of 65 years. Currently, there are only symptomatic treatment for PD and these do not mitigate the underlying causes of the disease.(...)