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Publicação
A 3D hepatic model to address immune‐mediated drug hepatotoxicity
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Autores
Orientador(es)
Resumo(s)
"The liver is a complex organ involved in many important physiological functions. Several
hepatic diseases, such as alcohol-related liver disease and drug-induced hepatotoxicity, are
associated with liver inflammation. Thus, it is of extreme relevance to understand the mechanisms
involved in liver inflammation to develop the best strategies to fight these diseases. The hepatic
macrophages, resident Kupffer cells and monocyte-derived macrophages, are known to play a
critical role in the liver inflammatory response. Although the diversity of experimental models
available to address hepatic diseases has been growing, there is still a need for models that can
depict the contribution of macrophages to the inflammatory response upon injury.(...)"
Descrição
Palavras-chave
Liver 3D culture macrophages Kupffer cells inflammation HepG2 cells
Contexto Educativo
Citação
Editora
Instituto de Tecnologia Química e Biológica António Xavier. Universidade NOVA de Lisboa.