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Biochemical and Biophysical Characterization of Exoribonucleases from the Human Pathogen Mycobacterium Tuberculosis
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| 4.79 MB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
"Mycobacterium tuberculosis, the causative agent of tuberculosis, remains the leading cause
of mortality from a single infectious organism, infecting nearly one-third of the global
population. Emergence of multidrug and extremely drug resistant strains of M. tuberculosis
represents a serious health problem and emphasizes the need to improve prevention and
control of the disease. Regulation of gene expression through RNA metabolism is a key
mechanism for bacterial growth, division and rapid accommodation to environmental
conditions. Ribonucleases ensure maturation, degradation and quality control of RNA in all
domains of life. (...)"
Descrição
Palavras-chave
RNA degradation Exoribonucleases Activity assays Thermal stability RNB-family Mycobacterium tuberculosis;