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Metabolism studies on emerging novel psychoactive substances (NPS) – Synthetic cathinones buphedrone and N-ethylhexedrone

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Master Thesis KBerkowicz 2020_VF.pdf4.57 MBAdobe PDF Ver/Abrir

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"Novel Psychoactive Substances (NPS) started emerging around two decades ago as a response to strict prohibition laws on common illicit drugs. They have been marketed as legal alternatives, sold openly in smartshops, dark web as adulterants of other drugs. The trend rose noticeably in the last decade, as the number of NPS monitored by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) rose from 13 in 2008 to 730 in 2018. Among them, synthetic cathinones (SC) became the most sought for class of NPS between users. They are particularly appealing to partygoers as some of the drugs from this class, such as Mephedrone, give effects similar to Ecstasy (MDMA) and cocaine, and were often cheaper and easier to obtain. As countries started to introduce restriction laws on the use of emerging SC, in response, new modified molecules would appear right after.(...)"

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Novel Psychoactive Substances Metabolism Studies Synthetic Cathiones Buphedrone N-ethylhexedrone Metabolites

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Instituto de Tecnologia Química e Biológia António Xavier. Universidade NOVA de Lisboa.

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