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Crystallographic studies of serine β-lactamase and serine proteases with novel inhibitors
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Resumo(s)
"Serine-based enzymes are present in many biological processes and are often chosen as promising
drug targets, since their deregulation lead to diseases, and study the 3D structure is essential to
understand how they interact with molecules capable of inhibiting their activity. This work aims for
structure determination by X-ray crystallography of protein complexes with novel inhibitors and results
from a collaboration established with Prof. Rui Moreira from iMed.ULisboa, who provided the ligands.(...)"
Descrição
Palavras-chave
Serine-based enzymes β-lactam-based inhibitors β-lactamase X-ray crystallography Elastase