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Profiting from light-induced metal-to-metal intramolecular electron transfer
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Resumo(s)
Photodynamic therapy is receiving increasing attention due to its versatile application in anticancer therapy. Ru(ii) and Pt(ii) complexes are among the most investigated compounds as potential photosensitizers for photodynamic therapy based on their outstanding photophysical and biological properties (i.e., strong emission, high intersystem crossing efficiency, large Stokes shift, high (photo-)stability, biological compatibility, good water solubility). While these classes of compounds have been widely studied separately or combined in derivatives that display a dual therapeutic effect, herein, a novel study on the conjugation of Ru(ii) and Pt(ii) fragments into a single bimetallic conjugate is proposed. It is assumed that this molecular design could undergo an intramolecular electron transfer from the Ru(ii) moiety to the Pt(ii) moiety upon irradiation to produce a highly efficient excited state. Capitalizing on the presence of both metals, the bimetallic conjugate was found to generate singlet oxygen with an outstanding efficiency in comparison to its individual components. To enhance the pharmacological profile, the bimetallic complex was encapsulated into polymeric nanoparticles. The nanoparticles were demonstrated to eradicate human breast adenocarcinoma monolayer cells as well as multicellular tumor spheroids upon light irradiation at nanomolar concentrations. We are confident that this approach will open new avenues towards the development of novel highly efficient photosensitizers.
Descrição
Funding Information: J. K. gratefully acknowledges the financial support provided by the Liebig fellowship from the Chemical Industry Fund of the German Chemical Industry Association, the Life Sciences Bridge Award from the Aventis Foundation, and the Paul Ehrlich & Ludwig Darmstaedter Early Career Award 2024 \u2013 a prize awarded by the Paul Ehrlich Foundation, Germany. G. E. acknowledges the financial support provided by Ministerio de Ciencia e Innovaci\u00F3n/Agencia Estatal de Investigaci\u00F3n (MCIN/AEI) of Spain (PID2021-127187OB-C21). J. S. V. acknowledges his predoctoral grant to Universidad de Burgos (2019/00002/008/001) and the PhD Exchange Scholarship provided by RUB Research School. J. V. C. V. acknowledges the financial support provided by Ministerio de Ciencia e Innovaci\u00F3n/Agencia Estatal de Investigaci\u00F3n (MCIN/AEI) of Spain (PID2022-142318NB-I00). Publisher Copyright: © 2025 The Royal Society of Chemistry.
Palavras-chave
Inorganic Chemistry