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Profiting from light-induced metal-to-metal intramolecular electron transfer

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dc.contributor.authorSanz-Villafruela, Juan
dc.contributor.authorServos, Lisa Marie
dc.contributor.authorMontesdeoca, Nicolás
dc.contributor.authorCuevas-Vicario, José V.
dc.contributor.authorMoro, Artur J.
dc.contributor.authorLima, João C.
dc.contributor.authorMartínez-Alonso, Marta
dc.contributor.authorEspino, Gustavo
dc.contributor.authorKarges, Johannes
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionFaculdade de Ciências e Tecnologia (FCT)
dc.contributor.pblRSC - Royal Society of Chemistry
dc.date.accessioned2025-07-31T21:19:23Z
dc.date.available2025-07-31T21:19:23Z
dc.date.issued2025
dc.descriptionFunding Information: J. K. gratefully acknowledges the financial support provided by the Liebig fellowship from the Chemical Industry Fund of the German Chemical Industry Association, the Life Sciences Bridge Award from the Aventis Foundation, and the Paul Ehrlich & Ludwig Darmstaedter Early Career Award 2024 \u2013 a prize awarded by the Paul Ehrlich Foundation, Germany. G. E. acknowledges the financial support provided by Ministerio de Ciencia e Innovaci\u00F3n/Agencia Estatal de Investigaci\u00F3n (MCIN/AEI) of Spain (PID2021-127187OB-C21). J. S. V. acknowledges his predoctoral grant to Universidad de Burgos (2019/00002/008/001) and the PhD Exchange Scholarship provided by RUB Research School. J. V. C. V. acknowledges the financial support provided by Ministerio de Ciencia e Innovaci\u00F3n/Agencia Estatal de Investigaci\u00F3n (MCIN/AEI) of Spain (PID2022-142318NB-I00). Publisher Copyright: © 2025 The Royal Society of Chemistry.
dc.description.abstractPhotodynamic therapy is receiving increasing attention due to its versatile application in anticancer therapy. Ru(ii) and Pt(ii) complexes are among the most investigated compounds as potential photosensitizers for photodynamic therapy based on their outstanding photophysical and biological properties (i.e., strong emission, high intersystem crossing efficiency, large Stokes shift, high (photo-)stability, biological compatibility, good water solubility). While these classes of compounds have been widely studied separately or combined in derivatives that display a dual therapeutic effect, herein, a novel study on the conjugation of Ru(ii) and Pt(ii) fragments into a single bimetallic conjugate is proposed. It is assumed that this molecular design could undergo an intramolecular electron transfer from the Ru(ii) moiety to the Pt(ii) moiety upon irradiation to produce a highly efficient excited state. Capitalizing on the presence of both metals, the bimetallic conjugate was found to generate singlet oxygen with an outstanding efficiency in comparison to its individual components. To enhance the pharmacological profile, the bimetallic complex was encapsulated into polymeric nanoparticles. The nanoparticles were demonstrated to eradicate human breast adenocarcinoma monolayer cells as well as multicellular tumor spheroids upon light irradiation at nanomolar concentrations. We are confident that this approach will open new avenues towards the development of novel highly efficient photosensitizers.en
dc.description.versionpublishersversion
dc.description.versioninpress
dc.format.extent2520140
dc.identifier.doi10.1039/d5qi00924c
dc.identifier.issn2052-1553
dc.identifier.otherPURE: 119238881
dc.identifier.otherPURE UUID: 70ee95e9-28ff-41e0-9fd3-cca11d340959
dc.identifier.otherScopus: 105005432838
dc.identifier.otherWOS: 001485988500001
dc.identifier.urihttp://hdl.handle.net/10362/185841
dc.identifier.urlhttps://www.scopus.com/pages/publications/105005432838
dc.language.isoeng
dc.peerreviewedyes
dc.subjectInorganic Chemistry
dc.titleProfiting from light-induced metal-to-metal intramolecular electron transferen
dc.title.subtitletowards highly efficient heterodinuclear photosensitizers for photodynamic therapyen
dc.typejournal article
degois.publication.titleInorganic Chemistry Frontiers
dspace.entity.typePublication
rcaap.rightsopenAccess

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