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Dietary Modulation of Cell Competition: Implications in Alzheimer’s Disease in a Drosophila Model
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| 6.9 MB | Adobe PDF |
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Resumo(s)
"Transmembrane Flower (Fwe) protein isoforms mediate cell competition,
tagging cells for elimination based on fitness. Winner cells express FweUbi, while
loser cells express FweLose isoforms, leading to apoptosis through azot activation.
This mechanism is linked to Alzheimer’s disease (AD) and cancer, as described in
Drosophila, mice and humans. Despite extensive research on AD, effective
treatments remain elusive. In this study, we use a humanized Drosophila AD model
to explore the functional conservation of human FWE isoforms (hFWE) and assess
the influence of nutritional regimens on cell competition and AD progression.(...)"
Descrição
Palavras-chave
Drosophila melanogaster human Flower isoforms Alzheimer’s Disease azot humanized model diet