Publicação
Dietary Modulation of Cell Competition: Implications in Alzheimer’s Disease in a Drosophila Model
| datacite.subject.fos | Ciências Naturais | pt_PT |
| dc.contributor.advisor | Moreno, Eduardo | |
| dc.contributor.advisor | Pereira, Catarina | |
| dc.contributor.author | Rodrigues, Maria Carolina | |
| dc.date.accessioned | 2025-05-22T14:40:24Z | |
| dc.date.embargo | 2027-09-30 | |
| dc.date.issued | 2025-02-25 | |
| dc.date.submitted | 2024-09-30 | |
| dc.description.abstract | "Transmembrane Flower (Fwe) protein isoforms mediate cell competition, tagging cells for elimination based on fitness. Winner cells express FweUbi, while loser cells express FweLose isoforms, leading to apoptosis through azot activation. This mechanism is linked to Alzheimer’s disease (AD) and cancer, as described in Drosophila, mice and humans. Despite extensive research on AD, effective treatments remain elusive. In this study, we use a humanized Drosophila AD model to explore the functional conservation of human FWE isoforms (hFWE) and assess the influence of nutritional regimens on cell competition and AD progression.(...)" | pt_PT |
| dc.identifier.tid | 101814496 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10362/183315 | |
| dc.language.iso | eng | pt_PT |
| dc.relation | Unravelling the link between Cell Competition and Alzheimer´s Disease | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Drosophila melanogaster | pt_PT |
| dc.subject | human Flower isoforms | pt_PT |
| dc.subject | Alzheimer’s Disease | pt_PT |
| dc.subject | azot | pt_PT |
| dc.subject | humanized model | pt_PT |
| dc.subject | diet | pt_PT |
| dc.title | Dietary Modulation of Cell Competition: Implications in Alzheimer’s Disease in a Drosophila Model | pt_PT |
| dc.type | doctoral thesis | |
| dspace.entity.type | Publication | |
| oaire.awardNumber | SFRH/BD/137397/2018 | |
| oaire.awardTitle | Unravelling the link between Cell Competition and Alzheimer´s Disease | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F137397%2F2018/PT | |
| person.familyName | Rodrigues | |
| person.givenName | Maria Carolina | |
| person.identifier.ciencia-id | CD1C-3F7D-1A49 | |
| person.identifier.orcid | 0000-0002-1108-4049 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.embargofct | Artigos por publicar | pt_PT |
| rcaap.rights | embargoedAccess | pt_PT |
| rcaap.type | doctoralThesis | pt_PT |
| relation.isAuthorOfPublication | 77082bf5-6b95-4cf1-bce6-4482d8979b6b | |
| relation.isAuthorOfPublication.latestForDiscovery | 77082bf5-6b95-4cf1-bce6-4482d8979b6b | |
| relation.isProjectOfPublication | e123cf74-b4c5-433e-9380-38c5ec6fe3e4 | |
| relation.isProjectOfPublication.latestForDiscovery | e123cf74-b4c5-433e-9380-38c5ec6fe3e4 | |
| thesis.degree.name | Dissertation presented to obtain the PhD degree in Molceular Biosciences | pt_PT |
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