A carregar...
Publicação
Insights into the mechanistic basis of disease tolerance in Drosophila melanogaster
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 15.32 MB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
Host-pathogen interactions during infection involve a complex interplay between disease causing agents (viruses, bacteria, fungi, protists, etc) and their hosts. Both host and pathogens
are known to employ various physiological and evolutionary adaptation strategies to promote
survival. These interactions between host and pathogens are commonly studied and
described at the population level (e.g. viral infections in a human population), at the organismal
level (e.g. pathogenic bacteria infecting a host), or at the molecular level (pathogen protein
binding to a receptor on a human cell). At every stage of this interaction, pathogens utilise
virulence factors and, in some instances pathogen-specific enzymes to evade host defence
systems, establish infection by promoting replication within specific host tissues or organs,
and evolve to maximise transmission from one host to another. This process inevitably results
in tissue and organ damage, leading to fitness costs to the host and even death(...)"
Descrição
Palavras-chave
insect model Drosophila melanogaster combat infections host-pathogen disease tolerance