Insights into the mechanistic bases of disease tolerance in Drosophila melanogaster

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Insights into the mechanistic basis of disease tolerance in Drosophila melanogaster

Publication . Akyaw, Priscilla Abena; Sucena, Élio

Host-pathogen interactions during infection involve a complex interplay between disease causing agents (viruses, bacteria, fungi, protists, etc) and their hosts. Both host and pathogens are known to employ various physiological and evolutionary adaptation strategies to promote survival. These interactions between host and pathogens are commonly studied and described at the population level (e.g. viral infections in a human population), at the organismal level (e.g. pathogenic bacteria infecting a host), or at the molecular level (pathogen protein binding to a receptor on a human cell). At every stage of this interaction, pathogens utilise virulence factors and, in some instances pathogen-specific enzymes to evade host defence systems, establish infection by promoting replication within specific host tissues or organs, and evolve to maximise transmission from one host to another. This process inevitably results in tissue and organ damage, leading to fitness costs to the host and even death(...)"

2025-03-25Tese de doutoramento

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Fundação para a Ciência e a Tecnologia

Número da atribuição

2020.06404.BD