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Preventing Clostridioides difficile infection by using an immobilized bile salt hydrolase to interfere with spore germination
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Resumo(s)
"The anaerobe Clostridioides difficile is a leading cause of healthcare-associated
infections. C. difficile infection occurs after faecal-oral transmission of spores that
germinate in the gut in response to certain bile salts. Commensal microbiota prevents
spore germination by modulating the bile acid pool. Therefore, spore germination, toxin
production and disease only occurs under dysbiosis, normally caused by antibiotic
therapy. Lactobacillus salivarius is a commensal bacterium that produces a 76 kDa
dimeric bile salt hydrolase (BSH). BSH catalyses the deconjugation of taurocholic acid
in cholic acid and taurine and inhibits C. difficile spore germination and colonization in
vivo.(...)"
Descrição
Palavras-chave
Bacillus subtilis spore display Lactobacillus salivarius bile salt hydrolase CotA